We describe a case of a mandibular ameloblastoma with a 17year history of local recurrences followed by two metachronous intracranial metastases. Ameloblastoma is the most common benign odontogenic tumor usually located in the jaw bone. Usual granular cell ameloblastoma is histologically characterized by granular changes of stellate. Kattimani v, sumanti j, prasad lk 2015 granular cell ameloblastoma.
Antigenic heterogeneity in granular cell ameloblastoma. Although rare in unicystic or cystic ameloblastoma, granular cell change in ameloblastoma is a recognized phenomenon. They are thought to arise from the cells that surround and insulate the nerve cells in our body schwann cells. Clinical and radiologic behaviour of ameloblastoma in 4 cases. Dinraj kulkarni 1, yashwant ingale 1, manjusha ingale 1, bomble nikhil ajabrao 2, mrinal mayank 3, apurva kulkarni 4 1 department of oral and maxillofacial pathology, m. Here we report a case of another type of granular cell ameloblastoma, showing predominant anastomosing double. Granular cell ameloblastoma is a rare condition, accounting for 35% of all ameloblastoma cases. Rangoonwala college of dental sciences and research center. Granular cell tumors gcts are extremely rare lesions of the urinary bladder with only nine cases being reported in world literature of which one was malignant. Most granular cell tumors are benign noncancerous, although some may be locally aggressive. The possibility of granular component is there in other odontogenic and nonodontogenic lesions. The granular cell odontogenic tumour is a type of odontogenic tumour featuring a proliferation of large cells with eosinophilic granular cytoplasm, which appear similar to the cells of granular cell ameloblastoma.
Granular cell ameloblastoma of mandible jansari tr. They are very rare lesions which have been reported in patients of a wide age range with a female predilection. Granular cell ameloblastoma of jaw report of a case with an emphasis on its characterization. Granular cell ameloblastoma represents a rare variant of ameloblastoma. Ameloblastoma is an epithelial odontogenic tumor exhibiting diverse microscopic pattern that occurs singly or in combination with other patterns. Basal cell ameloblastoma bca is the rarest histologic subtype in which the tumour is composed of numerous odontogenic epithelial islands supported by fibrous connective tissue.
The characteristic microscopic features of granular cells are attributed to. Granular cell tumors gcts are soft tissue tumors that can occur anywhere in the body. Granular cell ameloblastoma is a rare histological subtype of ameloblastoma accounting for less than 5% of the total. Generally believed to be of neural origin based on histochemical, immunohistochemical, and ultrastructural studies. A case report of granular cell ameloblastoma associated with aneurysmal bone cyst like features sriram kaliamoorthy 1, pazhani ambiga 2, shivakumar sivaraman 2, kanmani shanmugasundaram 3, mahendirakumar nagarajan 4 1 department of oral and maxillofacial pathology, chettinad dental college and research institute, chettinad health city. Ultrastructure of granular cell ameloblastoma navarrete.
In this paper, a case of aot in the anterior maxillary region associated with a permanent lateral incisor will be reported. Central nervous system metastasis without pulmonary involvement is. It exhibits histological variation which includes follicular, acanthomatous, granular cell, desmoplastic, basal cell, keratotic, calcifying, osteoplastic and ossifying types. Histologically, the lesion resembled simple ameloblastoma, but differed from the latter in that it contained many cells with granular eosinophilic cytoplasm. Granular cell ameloblastoma of jaw report of a case with. Pdf granularity in granular cell ameloblastoma yoithap. Recurrent ameloblastoma of the mandible with unusual. Granular cell changes can result from the cytoplasmic accumulation of various types of material, and the cell particularly prone to undergo the. Investigation of basement membrane proteins in a case of. Ameloblastoma is an aggressive locally recurring neoplasm of odontogenic epithelium. It is known to be locally more aggressive, with a higher chance of recurrence compared with other subtypes.
The average duration of symptoms in the granular cell ameloblastomas was 15. The granular cell ameloblastoma is s100 protein and alpha1antitrypsin positive. This article describes a case of granular cell ameloblastoma in a 29 year old male patient with clinical, radiology and histological findings along with a. It is due to an increased number of secondary lysosomes, as evidenced by immunoreactivity to cd68, which is a macrophage marker related to lysosomal glycoproteins. The purpose of the present article is to report a case of cystic granular cell ameloblastoma in 34.
A case report of granular cell ameloblastoma associated. A case of granular cell ameloblastoma was studied by light and electron microscopy. This often extends to include the peripheral columnar or cuboidal cells as well. The granular cell ameloblastoma gca is one of the rarest entities and accounts for only 5% of all ameloblastomas. Nikitakis 1, fotios tzerbos 2, kyriaki triantafyllou 1, christos papadimas 2, alexandra sklavounou 1. Ameloblastoma is a neoplasm of odontogenic epithelium, especially of enamel organtype tissue that has not undergone differentiation to the point of hard tissue formation. Massive granular cell ameloblastoma with dural extension and atypical morphology vandana raghunath 1, rachna rath 2, firoz kamal 1, satya ranjan misra 3 1 department of oral and maxillofacial pathology, narayana dental college and hospital, nellore, andhra pradesh, india 2 department of oral and maxillofacial pathology, scb dental college and hospital, cuttack. The granular cell ameloblastoma is characterized by the presence of large masses of granular cells located within the follicles figure 1. Ameloblastoma of the mandible with intracranial metastasis. The cells are large, round, or polyhedral, and densely packed with eosinophilic granules and frequently demonstrate welldefined borders but, in some instances, form. Ultrastructurally, the cytoplasmic granules were identified as lysosomes. T1 recurrent ameloblastoma of the mandible with unusual granular cell component. Granular cell ameloblastoma of the jaw a report of two cases with fine needle aspiration cytology archana deshpande, m.
Granular cell pattern is rarely seen in ameloblastoma, and is characterised by nests of large eosinophilic granular cells. Granular cell ameloblastoma marked transformation of the cytoplasm, usually of the stellate reticulum like cells very coarse, granular, eosinophilic appearance. N2 ameloblastomas can present in various clinical and histomorphologic. They are thought to be of histological interest only and do not affect the treatment or prognosis. Granular cell ameloblastoma gca is one of the rare histological variants of ameloblastoma 1. Granular cell ameloblastoma is a rare condition, accounting for 3. Pdf granular cell ameloblastoma gca is one of the rare histological variants of ameloblastoma 1. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium ameloblasts, or outside portion, of the teeth during development much more commonly appearing in the lower jaw than the upper jaw. These organelles were particularly abundant in cells.
Massive granular cell ameloblastoma with dural extension. The morphology of all granular cells is similar, but their origins are different. Granular cell ameloblastoma of the jaw researchgate. To our knowledge, this is the first description of the ultrastructure of the granular cell ameloblastoma, an odontogenic tumor. The mandible is the most common site of occurrence for both ameloblastic carcinoma types.
The purpose of this article is to present a case of unusual variant of ameloblastoma and highlighting its unique microscopic features that allow its distinction from other jaw tumors with a granular cell consistency. Peripheral ameloblastoma pa is a tumor that develops in the gingival epithelium or the alveolar bone surface 3,4. The most common is subtype is acanthomatous ameloblastoma 4, whilst granular cell ameloblastoma is the rarest, with no known reported cases in the literature until now. The organelles resulting in their cytoplasmic eosinophilia, as seen in the light microscope, are mainly pleomorphic, osmiophilic lysosome. The granular cell ameloblastoma gca is one of the rarest entities and accounts for only 5% of all ameloblastomas 5. The granular cells of this tumor are shown to be epithelial in origin. Granular cell differentiation is hallmarked by the presence of abundant eosinophilic granularity of cytoplasm. The characteristic microscopic features of granular cells are attributed to the increased presence of lysosomes in the cytoplasm of the tumour cells. Malignant ameloblastoma based on histological type 1. The granular cell variant of ameloblastoma is a rare condition, accounting for 3. Microscopically, the lesion showed small groups or large clusters of granular neoplastic cells, with pyknotic and hyperchromatic nuclei, oriented away from the basement membrane, in a backtoback arrangement. We are reporting a case of an ameloblastoma which arose in the wall of a dentigerous cyst.
This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the french physician louischarles malassez. Rangoonwala college of dental sciences and research center, pune. Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor, while unicystic ameloblastoma is a relatively less aggressive variant. Ameloblastoma is a benign tumour of odontogenic epithelial origin with several histological variants comprising of follicular, plexiform, acanthomatous, desmoplastic, granular cell and basal cell types. Ameloblastoma is a benign and locally aggressive epithelial odontogenic tumor, most commonly located in the mandible mainly in the molar and the ramus region. The granular appearance of the tumor cells can be seen in various oral tumors, such as granular cell ameloblastoma, granular cell myoblastoma, congenital epulis and granular cell ameloblastic fibromas. A case of bone expansion in the mandible of 65 year old patient was. The biological behavior of granular cell ameloblastoma does not seem to differ from the other histologic subtypes of ameloblastoma. A case of granular cell ameloblastoma gca was studied by light microscopy and histochemistry. The purpose of this article is to present a case of unusual variant of ameloblastoma and highlighting its unique microscopic features that allow its distinction from. This article describes a case of granular cell ameloblastoma gca involving mandible in a 55yearold male. H and e stained sections showed large odontogenic islands showing peripheral ameloblastlike cells and central stellate reticulumlike.
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